By: Matthias Niemann, Yara Strehler, Nils Lachmann, Fabian Halleck, Klemens Budde, Gideon Hönger, Stefan Schaub, Benedict M. Matern and Eric Spierings
Published: in Frontiers in Immunology 2022; 13:1005601.
Patients: 536
Highlights:
- First clinical validation of Snowflake algorithm in two clinical cohorts
- 305 kidney transplant monitored for donor-specific HLA antibodies (DSA)
- 231 pregnant women monitored for child-specific HLA antibodies (CSA)
- Comparison of Eplet matching (AbV and non-AbV), PIRCHE and Snowflake
- In DSA/CSA-positive cases, Snowflake scores were elevated
- Snowflake scores correlate stronger with Eplet scores than with PIRCHE