By: Matthias Niemann, Benedict M. Matern, Eric Spierings
Published: in Frontiers in Immunology 2022.
Highlights:
- Integrated deep learning protein surface prediction considering 676 HLA Class-I experimental structures and 37 Alphafold-predicted structures
- Residues’ solvent-accessibility but not geometric position is protein-specific
- Eplets in the HLA Epitope Registry show patterns of solvent-accessibility with
- Consistently accessible residues
- Only subsets of an epitope’s residues being consistently accessible
- Varying surface accessibility of residues of epitopes
- Calculation of donor-allele-specific solvent-accessible amino acid mismatches was implemented in the PIRCHE web service