Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) Are Associated with Poorer Outcome after Single Mismatch Unrelated Donor Stem Cell Transplantation: A Study of the Cooperative Transplant Study Group (KTS) of the German Group for Bone Marrow and Stem Cell Transplantation (DAG-KBT)

By:  Francis Ayuk, Martin Bornhäuser, Matthias Stelljes, Tatjana Zabelina, Eva-Maria Wagner, Christoph Schmid, Maximilian Christopeit, Martina Guellstorf, Nicolaus Kröger, Wolfgang Bethge

Published: in Transfusion Medicine and Hemotherapy 2019; 46:370–375.

Patients: 1997

Highlights:

• PIRCHE were associated with higher incidence of cGvHD, reduced overall survival and non-relapse mortality in 9/10 matched unrelated allo-HSCT