By: Shintaro Sakamoto, Kenta Iwasaki, Toshihide Tomosugi, Matthias Niemann, Eric Spierings, Yuko Miwa, Kosei Horimi, Asami Takeda, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai, Takaaki Kobayashi
Published: in Frontiers in Immunology 2020; Volume 11, August 2020, p.2000.
Patients: 691
Highlights:
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Study aims to elucidate the association of eplet mismatches and predicted indirectly recognizable HLA epitopes (PIRCHE) scores with de novo DSA production.
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Weak correlation between eplet mismatches and PIRCHE scores was identified, although both measurements were associated with classical HLA mismatches. Class II (DRB+DQB) eplet mismatches were significantly correlated with the incidence of de novo class II (DR/DQ) DSA production.
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PIRCHE scores were also significantly correlated with de novo class II DSA production
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Patients with low levels of both class II eplet mismatches and PIRCHE scores developed de novo class II DSA only in 4/179 (2.2%).
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The study concludes that the analysis of T cell and B cell epitopes can provide beneficial information on the design of individualized immunosuppression regimens for prevention of de novo DSA production after kidney transplantation.