By: J.M.Ladowski, Haddon Mullins, Margaret Romine, David Kloda, Carlton Young, Vera Hauptfeld-Dolejsek, Julie Houp, Jayme Locke
Published: in Cell Transplantation 2016; 25(11):2041-2050
Patients: 113
Highlights:
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Retrospective application of high-resolution incompatibility scoring to gauge the performance of EMMA, HLAMatchmaker and PIRCHE-II in predicting dn DSA formation in simultaneous pancreas-kidney (SPK) recipients.
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Statistically significant factors associated with dn DSA development are found for PIRCHE II and HLA Matchmaker.
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The report demonstrates that an increased incompatibility score predicts dn DSA development and worse renal and pancreas graft outcomes with dnDSA development.