By: Christian Unterrainer, Bernd Döhler, Matthias Niemann, Nils Lachmann, Caner Süsal
Published: in Immunology 2021; Front. Immunol. 12:631246 (February 2021).
Patients: 68606
Highlights:
- PIRCHE-II scores calculated based on split antigen HLA-A, -B, -DRB1 typing and adjusted to the 0–6 range of HLA mismatches.
- PIRCHE-II scores correlated strongly with the number of HLA mismatches (Spearman ρ = 0.65, P < 0.001).
- The influence of PIRCHE-II was especially strong in presensitized and influence of HLA mismatches in non-sensitized recipients.
- With high HLA-incompatibility (4–6 mismatches), PIRCHE-II improved the positive impact of matching compared to applying only traditional HLA matching (HR = 1.097, P = 0.005).
- The results suggest that the PIRCHE-II score is useful and can be included into kidney allocation algorithms in addition to HLA matching.