By: Toshihide Tomosugi, Kenta Iwasaki, Shintaro Sakamoto, Matthias Niemann, Eric Spierings, Isao Nahara, Kenta Futamura, Manabu Okada, Takahisa Hiramitsu, Asami Takeda, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai, Takaaki Kobayashi
Published: in Frontiers in Immunology 2021; Front. Immunol. 12: 924.
Patients: 578
Highlights:
- In pre-sensitizing events, preformed donor-reactive CD4+ memory T cells may induce early immune responses after transplantation.
- This study evaluates shared T cell epitopes (TEs) between the pre-sensitizing and donor HLA using an in silico assay, an alternative to estimate donor-reactive CD4+ memory T cells before transplantation.
- The study concludes that the evaluation of shared TEs for estimating preformed donor-reactive CD4+ memory T cells may help predict the risk of early de novo DSA formation after kidney transplantation.