Computational Eurotransplant kidney allocation simulations demonstrate the feasibility and benefit of T-cell epitope matching

By: Matthias Niemann, Nils Lachmann, Kirsten Geneugelijk, Eric Spierings

Published: in PLoS Computational Biology 2021; Jul 27;17(7):e1009248.

Highlights:

  • Markov chain Monte Carlo simulation of Eurotransplant kidney allocation system
  • Replacing HLA matching by PIRCHE epitope matching yields improved PIRCHE-II scores
  • No major impact on allocation-specific parameters observed