By: Matthias Niemann, Benedict M. Matern, Eric Spierings, Stefan Schaub, Gideon Hönger
Published: in Frontiers in Immunology 2021; 5364.
Patients: 231
Highlights:
- Analyzed 231 pregnancies as model system
- 11 loci high-resolution typing of all individuals
- Confirms PIRCHE presented by HLA-DRB1 along with HLA-DRB3/4/5, -DQ, and -DP are significant predictors for development of CSA
- Combining multiple presenting loci in a single predictor improved the model only marginally
- PIRCHE further improved through normalization by respective presenters’ binding promiscuity