Immunologic Risk Stratification of Pediatric Heart Transplant Patients by Combining HlaMatchmaker and PIRCHE-II

By: Massimo Mangiola, Mitchell Ellison, Marilyn Marrari, C. Bentlejewski, J. Sadowski, D. Zern, Matthias Niemann, B. Feingold, S.A. Webber, A. Zeevi, Anne I Dipchand, Jaqueline M Lamour, William T Mahle, Joseph W Rossano, Janet N Scheel, Tajinder P Singh, Warren A Zuckerman, CTOTC-09 site investigators

Published: in The Journal of Heart and Lung Transplantation 2022.

Patients: 131

Highlights:

  • Pediatric US heart transplant cohort
  • Patients with high eplet load appear less likely to develop DSA and ABMR if PIRCHE-II score is low
  • When used together, PIRCHE-II score allows to reclassify a portion of cases with high eplet load as having lower risk for developing DSA and ABMR