Impact of calcineurin inhibitor-free immunosuppression on de novo donor-specific antibody formation in liver transplant recipients

By: Magdalena Meszaros, Valérie Dubois, Nicolas Congy-Jolivet, Sarah Hamada, Céline Thevenin, Stephanie Faure, Olivier Boillot, Nassim Kamar, Georges-Philippe Pageaux, Arnaud Del Bello, Jérôme Dumortier

Published: in Liver International 2022; 42:1132–1143.

Patients: 727

Highlights:

  • 727 liver transplanted patients, of which 166 had CNI withdrawn
  • dnDSA incidence higher in CNI-free patients
  • dnDSA associated with abnormal liver graft histology
  • PIRCHE shown as independent risk factor for dnDSA