By: William Lemieux, David Fleischer, Archer Yi Yang, Matthias Niemann, Karim Oualkacha, William Klement, Lucie Richard, Constantin Polychronakos, Robert Liwski, Frans Claas, Howard M. Gebel11, Paul A. Keown, Antoine Lewin, Ruth Sapir-Pichhadze
Published: Frontiers in Immunology 2022; 13:1067075.
Patients: 118,309
Highlights:
- Article studies whether T cell molecular mismatches (TcEMM) are predictive of death censored graft failure (DCGF) in a retrospective cohort of kidney transplant patients.
- When applying the PIRCHE-II algorithm, 1,935 distinct TcEMMs were identified at the population level.
- 218 of the observed TcEMM were independently associated with DCGF by AFT models.
- Lasso penalized regression model with post selection inference identified a smaller subset of 86 TcEMMs (56 and 30 TcEMM derived from HLA Class I and II, respectively) to be highly predictive of DCGF. Of the observed TcEMM, 38.14% appeared as profiles of highly co-expressed TcEMMs. In addition, sensitivity analyses identified that the selected TcEMM were congruent across IMGT/HLA versions.