Association between PIRCHE-II scores and de novo allosensitization after reduction of immunosuppression during SARS-CoV-2 infection in kidney transplant recipients

By: Castrezana-Lopez et al

Published: in Transplant Infectious Disease 2023; Online

Patients: 47


  • Observational Cohort Study of 47 Kidney Transplant Recipients who underwent substantial reduction of maintenance immunosuppression during SARS-CoV-2 infection.
  • HLA-derived epitope mismatches were calculated using the PIRCHE-II algorithm.
  • Study concludes that the HLA-derived epitope mismatch load between donor and recipient influences the risk of de novo DSA development when immunosuppression is temporarily reduced.

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