By: Benedict M. Matern, Matthias Niemann
Published: Human Immunology 2024
Patients: 10,000 (virtual)
Highlights:
- PIRCHE scores are important in organ and stem cell transplantation due to their correlation with increased risks of donor-specific HLA antibodies and graft-versus-host disease, respectively.
- The PIRCHE application server has been updated to version 4.2, prompting the need to compare predicted scores with the previous version (3.3) to ensure consistency.
- A study compared PIRCHE version 4.2 with version 3.3 using a virtual cohort of 10,000 transplant pairs.
- In both stem cell and solid organ transplantation modules, the vast majority of cases showed identical PIRCHE scores between versions, with only 3% of cases showing deviations attributed to algorithm refinements. These differences were deemed clinically insignificant.