By: Emma T.M. Peereboom, Anna E. Maranus, Laura M. Timmerman, Kirsten Geneugelijk, Eric Spierings
Published: Transfusion Medicine and Hemotherapy (2024)
Patients: N/A
Highlights:
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Human leukocyte antigen (HLA)-DPB1 mismatches during hematopoietic stem cell transplantation (HSCT) with an unrelated donor increase the risk of graft-versus-host disease (GvHD).
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The PIRCHE algorithm predicts CD8+ T-cell epitopes available for indirect allorecognition and has been associated with GvHD development.
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PIRCHE-I analysis identified five HLA-DPB1-derived peptides capable of binding to HLA-A*02:01. These predictions were validated in vitro through binding assays and in vivo by inducing a T-cell response in mice.
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The study concludes that PIRCHE-I can identify immunogenic HLA-DPB1-derived peptides in HSCT recipients with HLA-DPB1 mismatches, supporting its potential role in predicting GvHD risk associated with these mismatches.